BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180. Based on data from yeast, we hypothesized that BAF180 may prevent tumorigenesis by promoting cohesion. Here, we show BAF180 is required for centromeric cohesion in mouse and human...

Sister Chromatid Cohesion and Aneuploidy

I-37: Genome Instability and DNA Damage in Male Somatic and Germ Cells Expressed as Chromosomal Microdeletion and Aneuploidy Is A Major Cause of Male Infertility

Background: Sperm chromatin insufficiencies leading to low sperm count and quality, infertility and transmission of chromosomal microdeletion and aneuploidies to next generations can be due to exposure to environmental pollutions, chemicals and natural or manmade ionizing radiation. In this project which has continued for more than 10 years and is unique in many technical aspects in Iran and in...

assessing political stability and instability in central asia and caucasus; case study, azerbaijan and kyrgyzstan

منطقه ی آسیای مرکزی وقفقاز به عنوان منطقه ای تاریخی و به دلیل دارا بودن ذخایر عظیم هیدرو کربنی از اهمیت ویژه ای برخوردار است. کشورهای این منطقه از عوامل عمده ی بی ثباتی نظیر عوامل جغرافیایی، اقتصادی، امنیتی، اجتماعی و سیاسی رنج می برند. پس از فروپاشی اتحاد جماهیر شوروی کشورهای منطقه از نعمت استقلال ناخواسته ای برخوردار شدند که مشکلات فوق را برای آن ها چندین برابر می کرد. در این روند برخی از این...

Sister chromatid cohesion control and aneuploidy.

Apart from a personal tragedy, could Down syndrome, cancer and infertility possibly have something in common? Are there links between a syndrome with physical and mental problems, a tumor growing out of control and the incapability to reproduce? These questions can be answered if we look at the biological functions of a protein complex, named cohesin, which is the main protagonist in the regula...